structural biology

structural biology
0 Wertungen (0 ø)

Structure biology determination is usually a tedious and expensive process whereby the target macromolecule must be produced in relatively large quantities and purified in high concentrations. A successful experiment often requires expert knowledge of biochemistry, bioinformatics and molecular biology. Over the past decades, rapid technical advances in DNA cloning, protein expression and purification methodologies have made it generally easy to obtain enough amount of proteins for their structural study. Besides, numerous innovations and improvements have been made in solving protein structures using instrumental methods such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy and electron microscopy (EM). These efforts together have given rise to dramatic accumulation of 3-D structural data in the past few decades (Figure 1). The large number of protein structures will certainly yield valuable information to the rules for elucidating protein folding/unfolding mechanisms and understanding their biological functions.

Alle Rechte vorbehalten

• Das Bild darf ohne die ausdrückliche Zustimmung des Autors weder kopiert noch verändert oder anderweitig genutzt werden.
 - Hochgeladen am 12.02.2018
302 Aufrufe
Die maximale Zeichenanzahl für einen Kommentar beträgt 1000 Zeichen.
Die maximale Zeichenanzahl für ein Pseudonym beträgt 30 Zeichen.
Bitte füllen Sie das Kommentarfeld aus.
Bitte einen gültigen Kommentar eingeben!