auristatin

auristatin
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Auristatin is a family of complex analogues to the native antineoplastic product dolastatin 10. They are 100 to 1000 times more toxic than Doxorubicin, a conventional cancer chemotherapy medication. The potent agent, dolastatin 10 is a five-subunit penta-peptide discroverde by Pettit et al. from the sea hare Dolabella auricularia in 1987 and chemical modification to dolastatin 10 were applied to generate auristatins.

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