maytansinoid

maytansinoid
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Antibody maytansinoid conjugates for cancer treatments. Maytansinoids were conjugated with lorvotuzumab (left) or trastuzumab (middle) via linkers bearing different release mechanisms (Mol Cancer Ther, 2010). Cleavable linkers undergo distinguished metabolism routes than non-cleavable linkers once internalized (right, Bioconjugate Chem, 2011).

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