cysteine drug

cysteine drug
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For conventional ADC production, 8 nucleophilic cysteine residues are first liberated from the reduced inter-chain disulfide bonds via reducing agents and they are later conjugated with drug-linker complexes. This approach generates ADCs with heterogeneous conjugation sites and a different number of drugs attached, resulting in a drug to antibody ratio (DAR) ranging from 0~8. As an example, Adcetris, one of the FDA approved ADCs, is prepared via non-specific cysteine drug conjugation.

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