lysine conjugation

lysine conjugation
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Many ADCs have been developed using lysine-based conjugation strategies. The FDA-approved gemtuzumab ozogamicin (trade name, Mylotarg) and trastuzumab emtansine (trade name, Kadcyla) are both generated by modifying the accessible lysine residues on the surface of the corresponding antibodies. Meanwhile, dozens of emerging ADCs under clinical evaluation are developed using lysine conjugation strategies, despite the potential of highly heterogeneous products with a relatively wide drug to antibody ratio (DAR) distribution.

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