Shiga Toxin! Image of the Week - April 10, 2017 - CIL:38952 - http://www.cellimagelibrary.org/images/38952

Shiga Toxin! Image of the Week - April 10, 2017 - CIL:38952 - http://www.cellimagelibrary.org/images/38952
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Shiga Toxin! Image of the Week - April 10, 2017

CIL:38952 - http://www.cellimagelibrary.org/images/38952

Description: A confocal micrograph of an intestinal biopsy from a child infected with shiga toxin-producing E. coli. Shiga toxin is an extremely potent toxin that is produced when the bacterium contains a bacteriophage carrying the toxin gene. It is closely linked with Haemolytic Uraemic Syndrome and acute renal failure in children. After ingestion via contaminated food or water the E. coli bacteria colonize the gut and produce the toxin, which then crosses the gastrointestinal barrier to enter the systemic circulation and reach the kidney and other target organs. In this image, the toxin (green) has crossed into the intestine and is binding to the endothelial cells of the lamina propria (red).

Author: S. Schuller

Licensing: Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales (CC BY-NC-ND 2.0 UK)

 

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 - Uploaded at 10.04.2017
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